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Comparison of Injected and Oral Polio Vaccine for Booster Immunization During the 1979 Polio Outbreak in Lancaster County, Pennsylvania

Published online by Cambridge University Press:  02 January 2015

Robert G. Doe ,
Bruce Kleger  and
John L. Randall
Robert G. Doe*
Affiliation:
Department of Family & Community Medicine, Lancaster General Hospital, Lancaster, Pennsylvania
Bruce Kleger
Affiliation:
Department of Family & Community Medicine, Lancaster General Hospital, Lancaster, Pennsylvania
John L. Randall
Affiliation:
Department of Family & Community Medicine, Lancaster General Hospital, Lancaster, Pennsylvania
*
Dept. of Family & Community Medicine, Lancaster General Hospital, P.O. Box 3555, 555 N. Duke St., Lancaster, PA 17603
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Abstract

During a 1979 outbreak of poliomyelitis in Lancaster County, Pennsylvania, we investigated the neccessity for and the response to booster vaccination of hospital personnel. The immune response of hospital employees who received booster injections of Salk vaccine (n=38) was compared with that of residents in the surrounding community who received Sabin trivalent OPV boosters (n=43). Serum neutralizing antibody titers to the three polio serotypes were measured before and after booster immunization. Results indicated that 38% of the subjects in both groups had low initial antibody titers. Salk vaccine was in all circumstances as effective or better than Sabin vaccine in increasing neutralizing IgG antibody titers [Infect Control 1981; 2(5):377-379.]

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 2 , Issue 5 , October 1981 , pp. 377 - 379
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1981

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References

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