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P01-68 - Factors Associated to Course of Symptoms in Bipolar Disorder: Acutely Depressed Versus Subthreshold Mixed Patients

Published online by Cambridge University Press:  17 April 2020

M. Mazza ,
L. Mandelli ,
M. Di Nicola ,
G. Martinotti ,
D. Harnic ,
A. Bruschi ,
V. Catalano ,
D. Tedeschi ,
R. Colombo  and
P. Bria
...Show all authors
M. Mazza
Affiliation:
Department of Neurosciences, Catholic University of Sacred Heart of Rome, Rome
L. Mandelli
Affiliation:
Department of Psychiatry, University of Bologna, Bologna
M. Di Nicola
Affiliation:
Department of Neurosciences, Catholic University of Sacred Heart of Rome, Rome
G. Martinotti
Affiliation:
Department of Neurosciences, Catholic University of Sacred Heart of Rome, Rome
D. Harnic
Affiliation:
Department of Neurosciences, Catholic University of Sacred Heart of Rome, Rome
A. Bruschi
Affiliation:
Department of Neurosciences, Catholic University of Sacred Heart of Rome, Rome
V. Catalano
Affiliation:
Department of Neurosciences, Catholic University of Sacred Heart of Rome, Rome
D. Tedeschi
Affiliation:
Department of Neurosciences, Catholic University of Sacred Heart of Rome, Rome
R. Colombo
Affiliation:
Department of Biochemistry, Catholic University of Sacred Heart of Rome, Rome, Italy
P. Bria
Affiliation:
Department of Neurosciences, Catholic University of Sacred Heart of Rome, Rome
A. Serretti
Affiliation:
Department of Psychiatry, University of Bologna, Bologna
L. Janiri
Affiliation:
Department of Neurosciences, Catholic University of Sacred Heart of Rome, Rome

Abstract

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Introduction

The purpose of this study is to contribute to the knowledge of the clinical characteristics of the bipolar spectrum by examining factors associated to course of symptoms in BP patients. We evaluated differences between acutely depressed versus subthreshold mixed patients.

Methods

90 depressed patients (Group 1, HDRS: 18.2±4.6, YMRS: 1.4±2.9) and 41 patients presenting a mixed subthreshold symptomathology (Group 2, HDRS: 9.1±3.2, YMRS: 9.6±6.4) were included in the study. All patients underwent structured diagnostic interviews for axis I and axis II disorders (SCID-I, SCID-II) and have been submitted to psychometric assessment with Hamilton Depression Rating Scale (HDRS), Hamilton Anxiety Rating Scale (HARS), Young Mania Rating Scale (YMRS), Global Assessment Scale (GAS), Social Adjustment Self-reported Scale (SASS), Quality of Life Scale (QoL), at baseline and repeated follow-up (1, 3, 6, 12 months). Personality dimensions were evaluated by Temperament and Character Inventory (TCI-R).

Results

The most important result is the slight increase in depressive symptoms in subthreshold mixed patients after 3 months of treatment. These patients were more likely diagnosed as BP-I, were non-SUD patients and/or non-comorbid for axis II personality disorders and had a shorter duration of current episode prior intake. Measures of social and functional adjustment were not different in the two groups, though a slight trend for depressed patients to report a poorer quality of life. No difference in personality traits were observed among the two samples.

Conclusions

Our study confirms the importance of considering subthreshold symptoms in the evaluation and treatment of patients with Bipolar Disorder.

Type
Affective disorders / Unipolar depression / Bipolar disorder
Information
European Psychiatry , Volume 25 , Issue S1: 18th European Congress of Psychiatry. February 27, March 2, 2010 - Munich, Germany , 2010 , 25-E287
Copyright
Copyright © European Psychiatric Association 2010
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