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Early-life adversity and adolescent depression: mechanisms involving the ventral striatum

Published online by Cambridge University Press:  16 December 2014

Bonnie Goff  and
Nim Tottenham
Bonnie Goff
Affiliation:
Department of Psychology, The University of California–Los Angeles, Los Angeles, California, USA
Nim Tottenham*
Affiliation:
Department of Psychology, Columbia University, New York, New York, USA
*
*Address for correspondence: Nim Tottenham, Columbia University, Psychology Dept., 406 Schermerhorn Hall, 1190 Amsterdam Avenue MC 5501, New York, NY 10027, USA. (Email: [email protected])
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Abstract

Early-life adversity is a well-established risk factor for the development of depression later in life. Here we discuss the relationship between early-life adversity and depression, focusing specifically on effects of early-life caregiver deprivation on alterations in the neural and behavioral substrates of reward-processing. We also examine vulnerability to depression within the context of sensitive periods of neural development and the timing of adverse exposure. We further review the development of the ventral striatum, a limbic structure implicated in reward processing, and its role in depressive outcomes following early-life adversity. Finally, we suggest a potential neurobiological mechanism linking early-life adversity and altered ventral striatal development. Together these findings may help provide further insight into the role of reward circuitry dysfunction in psychopathological outcomes in both clinical and developmental populations.

Keywords

adolescencecaregiver deprivationdepressionearly-life adversityventral striatum
Type
Review Articles
Information
CNS Spectrums , Volume 20 , Special Issue 4: Pediatric Neuroimaging , August 2015 , pp. 337 - 345
Copyright
© Cambridge University Press 2014 

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Footnotes

This work was supported by NIMH R01MH091864 (NT) and The Dana Foundation.

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