Hostname: page-component-cd9895bd7-jn8rn Total loading time: 0 Render date: 2024-12-28T14:09:16.694Z Has data issue: false hasContentIssue false
  • English
  • Français

Cerebellar glioblastoma: a clinicopathologic series of 16 cases

Published online by Cambridge University Press:  05 September 2019

M Abdollahi ,
AF Gao ,
H Okura ,
A Alsahlawi ,
C Hawkins ,
MD Cusimano  and
DG Munoz
M Abdollahi
Affiliation:
Dept of Laboratory Medicine, St Michael’s Hospital, Toronto, ON, Canada
AF Gao
Affiliation:
Dept of Laboratory Medicine, St Michael’s Hospital, Toronto, ON, Canada Dept of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
H Okura
Affiliation:
Division of Neurosurgery, Dept of Surgery, St Michael’s Hospital, Toronto, ON, Canada
A Alsahlawi
Affiliation:
Division of Neurosurgery, Dept of Surgery, St Michael’s Hospital, Toronto, ON, Canada
C Hawkins
Affiliation:
Dept of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada Dept of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, ON, Canada
MD Cusimano
Affiliation:
Division of Neurosurgery, Dept of Surgery, St Michael’s Hospital, Toronto, ON, Canada
DG Munoz
Affiliation:
Dept of Laboratory Medicine, St Michael’s Hospital, Toronto, ON, Canada Dept of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Due to their rareness, it is not known if the clinicopathological features of cerebellar glioblastomas (cGBMs) are different from supratentorial GBMs (sGBMs). We reviewed all 16 cases of cGBMs (total GBMs: 1350) at St. Michael’s Hospital over 18 years and assessed their clinicopathologic features. The mean age at diagnosis was 57 years. The most common presentations were headache (56%) and gait instability (56%). The majority (81%) of cGBMs were hemispheric while 19% involved the midline. There was radiologic evidence of brainstem infiltration at presentation in one case. Radiologically, peritumoral edema (63%) and heterogeneous contrast enhancement (50%) were common. Histologically, cGBM showed leptomeningeal involvement in 10/12 of cases. Uncommon histologic variants included 3 giant cell GBMs, a gliosarcoma, and a tumor with Rosenthal fibres and eosinophilic granular bodies. IDH1 R132H mutation was detected in 3/14 cases, a rate much higher than sGBMs. Additionally, 7/11 tumors had widespread p53 immunopositivity suggestive of TP53 mutation which is in accordance with previous reports in the literature. Of 9 cases tested, none had histone H3 K27M or G34R/V mutation. In summary, cGBMs have unique features that distinguishes them from sGBMs.

LEARNING OBJECTIVES

This presentation will enable the learner to:

  1. 1. Identify the clinicopathological features of cerebellar GBMs including major molecular alterations

  2. 2. Compare cerebellar and supratentorial GBMs and describe the distinguishing features of each type of tumor

Type
Abstracts
Information
Canadian Journal of Neurological Sciences , Volume 46 , Supplement s2: ABSTRACT: 58th Annual Canadian Association of Neuropathologists Meeting , September 2019 , pp. S65
Copyright
© The Canadian Journal of Neurological Sciences Inc. 2019