Supply chain management is a substantially complex area for many businesses due to its diverse set of actions, agents, decisions, risks, and uncertainties. Consequently, supply chains often break up in disarray due to their structural complexity coupled with risks and uncertainties in the absence of clear objectives. Işık Biçer addresses these issues by uncovering the fundamental trade-offs of supply chain management, their economic causes, and strategic implications. He offers a novel framework of supply chain management based on its role in economic systems. The framework shows four effective supply chain strategies according to business models and organizational sensitivity to operational trade-offs. Furthermore, it offers a detailed account of the digital transformation of supply chains, elaborating on crucial aspects of the design and implementation of digitalization. This is an indispensable source for supply chain professionals, consultants, economists, and policymakers with a keen interest in supply chain management.